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differential causes algorithm mcv rheumatology activation acute aki atlas bloodcell calculation chronic classification elevatedmcv erythematosus extravascular fatigue hemolysis hemolytic index
Medications causing Acute Kidney Injury (AKI) Prerenal: • Dehydration: Diuretics • Altered intrarenal autoregulation: ACEIs / ARBs,
sphincter tone: • Opiates ... decongestants) • Any drug ... #Medications #Drugs ... #pharmacology # ... differential #diagnosis
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
- Differential Diagnosis ... Megakaryopoiesis • Aplastic Anemia ... methotrexate) • Drugs ... anti-HLA antibodies Drugs ... Algorithm #Causes #Hematology
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Neoplastic / Hematologic ... • Anemia • ... Anti-Depressants • Drug ... Alcohol) • Drug ... Malnutrition / Drug
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential Diagnosis ... Orotic aciduria, Drugs ... (e.g., hydroxyurea ... #Differential #Diagnosis ... #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
- Differential Diagnosis ... Chronic Disease (e.g ... Deficiency • Drugs ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
infiltration (e.g ... Marrow suppression (e.g ... . drugs, chemotherapy ... Production #Index #hematology ... #diagnosis #calculation
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
- Differential Diagnosis ... Blood Smear • Drugs ... Increased Requirement (e.g ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Microangiopathic hemolytic anemia ... infection) - Drugs ... #differential #diagnosis ... #hematology #anemia
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Iron deficiency anemia ... Chemotherapy (e.g ... disorders, Oxidative drugs ... #differential #diagnosis ... #hematology #microscopy
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
) • Sepsis • Drug-induced ... with leukopenia, anemia ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
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