16 results
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Autoantibodies and ... Anti-histone - Drug-induced ... Goodpasture's syndrome #Autoantibodies ... Associations #diseases #diagnosis ... #table #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... vs SLE Drug Induced ... all lupus cases, drug-dependent ... - Less common (drug-dependent ... Discontinuation of causal drug
Drug Induced Systemic Lupus Erythematosus
> 100 drugs have been associated with drug-induced SLE
High risk (>5%):
 •
Drug Induced Systemic ... Erythematosus > 100 drugs ... associated with drug-induced ... #medications #drugs ... #rheumatology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... Lupus Mimickers: Drug-induced ... Lupusreference #SLE #Systemic ... #autoantibodies ... #differential #rheumatology
Back to the "10 Need to Know" series - Drug Therapeutic Target Levels. 

For lithium, target
Know" series - Drug ... vary depending on treatment ... Ranges #Toxicology #Pharmacology ... #Diagnosis #Table
Managing warfarin INR

Warfarin dosage must be individualized according to the patient's response to the drug, and
response to the drug ... management #algorithm #pharmacology ... #treatment #medications ... #table #pharmacotherapy ... decisionaid #cardiology #hematology
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
SLE (60-70%) & drug-induced ... #Antinuclear #autoantibodies ... erythematosus #diagnosis ... #rheumatology # ... table #ANA
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
) • Sepsis • Drug-induced ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
First Generation Anti-Psychotics: Mechanisms and Side Effects
Typical/Conventional Anti-Psychotics - Examples: Haloperidol, Chlorpromazine

ACh M1 antagonist - Block
arterioles -> less able ... VTA -> limbic system ... irreversible • Drug ... #SideEffects #pharmacology ... #diagnosis #psychiatry
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Anti-Ro/SSA autoantibodies ... Differential Diagnosis ... extremities Drug ... • Antihistone: Drug ... #Rheumatology