51 results
Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Hypereosinophilia ... and Hypereosinophilic ... Syndrome • Clinically ... Syndrome #HES #Hematology ... eosinophils #diagnosis #management
Hypereosinophilia (HE) Summary

 • Definition
 • When to Suspect?
 • A Partial Classification of Hypereosinophilia
 •
Hypereosinophilia ... Classification of Hypereosinophilia ... @ZhuoerXie #Hypereosinophilia ... #HE #hematology ... #diagnosis #management
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm
Sequestration:
 • Splenomegaly
Marrow Infiltration:
 • Hematologic and non-hematologic
Pancytopenia - Differential ... Sequestration: • Splenomegaly ... #Neutropenia #Differential ... Algorithm #Causes #Hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
Causes of Splenomegaly ... - Differential ... Acquired causes #Splenomegaly ... Spleen #Enlarged #Differential ... Algorithm #Causes #Hematology
Approach to Leukocytosis - Differential Diagnosis Algorithm

Features of hematologic malignancy:
 • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Leukocytosis - Differential ... lymphadenopathy, petechiae, splenomegaly ... #Leukocytosis #Differential ... Diagnosis #Algorithm #hematology
Causes of Leukocytosis and Leukopenia - Differential Diagnosis
 • Eosinophilia (AEC > 500, hypereosinophilia > 1500):
and Leukopenia - Differential ... Eosinophilia (AEC > 500, hypereosinophilia ... Leukocytosis #Leukopenia #Differential ... Diagnosis #causes #hematology
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
blood eosinophilia/hypereosinophilia ... 1,500 cells/µL • Hypereosinophilia ... Disorders #Algorithm #Differential ... #diagnosis #hematology
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
Pancytopenia - Differential ... studies, PT/aPTT Differential ... sequestration (splenomegaly ... #Pancytopenia #Differential ... Diagnosis #Algorithm #hematology
When to look for clonal/neoplastic hypereosinophilia (HEo)?
 - Exclusion of frequent causes (Drug-induced HEo, helminthiasis, cancer,
clonal/neoplastic hypereosinophilia ... ) - Clinical symptoms ... (Male gender, Splenomegaly ... #Neoplastic #hypereosinophilia ... Diagnosis #Signs #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Framework
Decreased Production:
 - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Thrombocytopenia - Differential ... Anything causing splenomegaly ... Thrombocytopenia #Differential ... Diagnosis #Framework #hematology