10 results
Coagulation Cascade and Anticoagulant Sites of Action

- Amy Chung, MD, MSc https://twitter.com/AmyChung

#AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
Coagulation Cascade ... #Medications #Pharmacology ... #Pathophysiology ... Mechanisms #DOAC #Hematology
Hemostasis Physiology

The blood's response to blood vessel injury can be viewed as four interrelated steps. 
Roman
four interrelated steps ... numerals refer to coagulation ... #Hemostasis #Pathophysiology ... #Coagulation #Cascade ... #Hematology
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm

DIFFUSE
Scarring - Irreversible-biopsy required
 • Lupus
• Lithium - Stress ... Psychological stress ... Diffuse #Focal #HairLoss ... #Alopecia #dermatology ... Diagnosis #Algorithm #causes
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Intravascular Coagulation ... protein C and S Pathophysiology ... Treat primary cause ... #diagnosis #causes ... treatment #management #hematology
Allopecia - Differential Diagnosis Framework for Hair Loss

Localized / Focal Hair Loss Pattern:
 • Scarring Alopecia:
Lithium • Stress ... Scaling, pustules, crusts ... Major psychologic stress ... Differential #Diagnosis #dermatology ... #Hairloss
Diffuse Hair Loss (Alopecia) - Differential Diagnosis Algorithm

Scarring - Irreversible-biopsy required
 • Lupus erythematosus
 • Lichen
• Lithium - Stress ... Psychological stress ... #Diffuse #HairLoss ... #Alopecia #dermatology ... Diagnosis #Algorithm #causes
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
considered in all cases ... intravascular coagulation ... and other causes ... Venous #Arterial #pathophysiology ... #hematology #differential
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
blood donor • Pathophysiology ... without other cause ... transfusion • Pathophysiology ... of (Acute resp distress ... Transfusion #Reactions #hematology
D-dimer
Plasma D-dimer is a product of clot breakdown, released upon degradation of polymerized, crosslinked fibrin. Elevated
indicate that coagulation ... age, which can cause ... Ddimer #dimer #pathophysiology ... #hematology #differential
Review of the Coagulation Cascade
Traditional Model:
 • Parallel extrinsic and intrinsic pathways.
Contemporary Model:
 • 4 key
Review of the Coagulation ... Initiation phase caused ... , resulting in coagulation ... diagnosis #models #hematology ... #pathophysiology