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diagnosis management differential oncology algorithm hemolytic chronic cll cold hemeonc leukemia lymphocytic syndrome acquired activation agglutinin aiha anticoagulation arteritis calculation
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Hemolytic Anemia ... Hemolytic Anemia ... Spherocytes • Treatment ... transient hemolysis • Treatment ... #hematology #diagnosis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... hemolysis, deficiency anemia ... Rebound effect from treatment ... Malignancy: Metastatic cancer ... Diagnosis #Algorithm #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... telomeropathy Cancer ... Inflammatory and Autoimmune ... Differential #Diagnosis #Hematology
Autoimmune Hemolytic Anemia (AIHA) Treatment Warm AIHA: 1) Steroids - 1-2 mg/kg prednisone daily • Until
Autoimmune Hemolytic ... Anemia (AIHA) Treatment ... #Hemolytic #Anemia ... #AIHA #Treatment ... #management #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
particular degree of anemia ... Index < 2: • Anemia ... infiltration (e.g. cancer ... • Hemolysis: Autoimmune ... Production #Index #hematology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
thrombocythemia), Autoimmune ... adsorption onto cancer ... Diagnosis #Management #treatment ... #hematology #differential
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Membrane): - Autoimmune ... Defects: Sickle cell anemia ... Laboratory Tests ... Differential #Diagnosis #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
5) Symptoms of anemia ... transformation) Treatment ... marrow failure with anemia ... AIHA, PRCA) • Treatment ... Leukemia #oncology #hematology
Treatment algorithm for VTE in Malignancy (A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
incidental DVT or PE in cancer ... thrombosis in cancer ... beyond 6 months should ... VTE #Malignancy #Cancer ... Anticoagulation #Management #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral infection, autoimmune ... CLL (older) • Autoimmune ... • Diagnostic Test ... Donath-Landsteiner test ... #hematology #diagnosis
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