93 results
Mechanisms of nephron damage in cardiorenal syndrome
 • Increased renal interstitial pressure
 • Hypoperfusion
 • Reduced
in cardiorenal syndrome ... • Increased renal ... hypertrophy • Sodium ... #cardiorenal #syndrome ... pathophysiology #nephrology
General approach to AKI - Checklist

Urine electrolytes & FENa - Previously, it was believed that urine
believed that urine sodium ... fractional excretion of sodium ... differentiate between pre-renal ... and intrinsic renal ... AcuteKidneyInjury #Nephrology
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
Epithelial Cells Renal ... cell epithelial sodium ... of epithelial sodium ... receptor Distal renal ... Defects #Kidney #Nephrology
Volume Based Approach to Hyponatremia
Hypovolemic, Serum uric acid >4
 • Urine Na <20: Extra-renal losses
 •
Na <20: Extra-renal ... Urine Na >30: Renal ... Cirrhosis, Nephrotic syndrome ... algorithm #diagnosis #sodium ... #low #nephrology
Hypernatremia Diagnosis and Workup

Step 1 . Repeat the sodium concentration.
Step 2.  Check plasma osmolality.
NORMAL PLASMA
Repeat the sodium ... - fevers • renal ... • nephrotic syndrome ... • renal failure ... Workup #Algorithm #Nephrology
Hyponatremia Differential Diagnosis Algorithm - Utilizing Uric Acid 
ADH promotes Urea/uric acid excretion along with water
Osmolarity 3) Urine Sodium ... High Uric Acid → renal ... Diagnosis #Algorithm #nephrology ... #sodium #low #uricacid
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
Localization of Renal ... Defects Fanconi Syndrome ... tubule Bartter Syndrome ... Henle Gitelman Syndrome ... Pathophysiology #Nephrology
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
mOsm/kg - Implies renal ... , Ingestion Renal ... , Cushing syndrome ... Workup #Algorithm #nephrology ... #sodium
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Algorithm Extra-renal ... loss (Diarrhea) Renal ... SAME, Cushing Syndrome ... , Gitelman syndrom ... potassium #low #nephrology
Causes of Hypernatremia - Differential Diagnosis
Inadequate water intake:
 • Lack of access to water
Extrarenal hypotonic fluid
perspiration Renal ... Diagnosis #Causes #nephrology ... #sodium #high