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differential sle systemic associations classification management cryoglobulinemia cryoglobulins druginduced mimickers patterns tafro thrombocytopenia types
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... cases • Sjögren syndrome ... Vasculitis: • ... #antibodies #diagnosis ... #rheumatology #
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Rheumatology • ... Lupus (SLE): ANA ... Syndrome: Anti-cardiolipin ... LAC) • Sjogren Syndrome ... Ill • ANCA Vasculitis
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
ANA - Non-specific ... c-ANCA - Vasculitis ... - Vasculitis, e.g ... #diagnosis #table ... #rheumatology #
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... SLE), Sjogren's Syndrome ... Arthritis, Sjögren Syndrome ... #Antibodies #ANA ... #patterns #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis: + MPO-ANCA ... Mucocutaneous lymph node syndrome ... : • Behçet Syndrome ... • Cogan Syndrome ... #rheumatology #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
ACLE) • Erythematous ... vasculitis, rheumatoid ... • Mesenteric vasculitis ... inflammation Cutaneous Vasculitis ... #Diagnosis #Rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... : - ANA 95-100% ... #Diagnosis #autoantibodies ... #signs #symptoms ... #differential #rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... searched for when ANA ... SLE-SSc-AlM overlap syndromes ... #diagnosis #rheumatology ... #table #ANA
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Hyperviscosity Syndrome ... Cryoglobulinemia Syndrome ... 20% Sjögren's syndrome ... DDX: • ANCA (Antineutrophil ... classification #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Workup: - ANA ... of autoantibodies ... Erythematosus ( ... Workup: - ANA ... #table #rheumatology
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