225 results
Tumor lysis syndrome (TLS) - Pathophysiology:
→ Massive tumor cell lysis
→ Release of large amounts of K+,
Tumor lysis syndrome ... (TLS) - Pathophysiology ... Massive tumor cell lysis ... TumorLysis #syndrome #TLS
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology of Tumor Lysis ... Syndrome (TLS) ... Tumor Cell Lysis ... TumorLysis #Syndrome #TLS
Tumor Lysis Syndrome - Workup and Management

Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Tumor Lysis Syndrome ... Treatment of Clinical TLS ... transfer • Tumor lysis ... MatthewHoMD #TLS ... #Tumor #Lysis #
Hyperkalemia - Differential Diagnosis - Impaired Excretion vs Redistribution

Impaired Urinary Excretion 
 - Renal failure
 -
Hyperkalemia - Differential ... Hypoaldosteronism Cell Lysis ... #Hyperkalemia #Differential ... #Diagnosis #Table
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS
Laboratory TLS:
 • Uric
Classification of Tumor Lysis ... Syndrome (TLS) ... Abnormalities of TLS ... Laboratory TLS ... mg/dL Clinical TLS
Hypermagnesemia - Etiologies by Mechanism
Renal Failure 
Excessive Mg Administration 
 - Massive PO intake
Mechanisms - Tumor lysis ... Hypermagnesemia #Differential ... High #Magnesium #Table
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis vs Tumor Lysis ... leukapheresis - TLS ... rasburicase Tumor Lysis ... Pathophysiology: Lysis ... #Syndrome #TLS
Monoclonal Gammopathy Testing
Strengths, Weaknesses and Accuracy Compared
 - SPEP 
 - IFE 
 - FLC
- IFE - FLC ... MGUS #SPEP #IFE #FLC ... Laboratory #Comparison #Table
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
• Light chain (LC ... nephropathy • LC ... DD • Proximal LC ... Interleukin-2) • Tumor lysis ... Cancer #Oncology #Differential
Hyperphosphatemia - Differential Diagnosis Algorithm
Transcellular Shift:
 • Rhabdomyolysis
 • Tumor Lysis
 • Metabolic or Respiratory Acidosis
Hyperphosphatemia - Differential ... Rhabdomyolysis • Tumor Lysis ... Hyperlipidemia • Tumor Lysis ... HighPhosphate #Differential