43 results
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology of Tumor Lysis ... Tumor Cell Lysis ... -> Allantoin (High ... Ca-Phos nephropathy (high ... Hypocalcemia • Hyperkalemia
Hyperkalemia: Diagnostic algorithm
Decreased renal potassium excretion
 • Acute renal failure
 • Chronic renal failure
 • Drugs
Increased
Hyperkalemia: Diagnostic ... algorithm Decreased ... transfusion • Tumor lysis ... Normal, Renin High ... #Diagnosis #algorithm
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... cytotoxic therapies in high-burden ... treatments) occur in high ... 6L/day) • For hyperkalemia ... #Syndrome #TLS
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
immature blasts and high ... leukapheresis - TLS ... Spontaneous if high ... hydration - Hyperkalemia ... #Syndrome #TLS
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS
Laboratory TLS:
 • Uric
Classification of Tumor Lysis ... Syndrome (TLS) ... Abnormalities of TLS ... Laboratory TLS ... hydroxide • Hyperkalemia
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... phlebotomy High ... release due to cell lysis ... reaction - Tumor lysis ... causes #potassium #high
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of
Tumor lysis syndrome ... hyperuricemia, #hyperkalemia ... #Presentation #TLS
Causes of HyperKalemia - Differential Diagnosis
Increased extracellular K+:
 • Tissue injury
 • Hemolysis
 • Rhabdomyolysis
 •
Causes of HyperKalemia ... Rhabdomyolysis • Tumor lysis ... glycosides • High ... MCW_Nephrology #HyperKalemia
Workup of Hypercalcemia - Differential Diagnosis Algorithm
High or Normal PTH:
 • Hyperparathyroidism: Parathyroid adenoma, Parathyroid hyperplasia,
Differential Diagnosis Algorithm ... High or Normal ... Low PTH: • High ... Syndromes - High ... Differential #Diagnosis #Algorithm
Diagnosis of Hypokalemia - Differential Algorithm 

Categorized by Causes: Redistribution, Extrarenal Losses, Renal Losses (High and
Diagnosis of Hypokalemia ... - Differential Algorithm ... Renal Losses (High ... #Diagnosis #Hypokalemia ... #Differential #Algorithm