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Guide to Acute Kidney Injury (AKI)

What to ask/look for: 
 - HPI, PMH, full ROS
- Urine Na/K/Cl ... /urea/protein/Cr ... related) - Glomerulonephritis ... AcuteKidneyInjury #AKI #Nephrology ... #Diagnosis #Algorithm
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
failure (glomerulonephritis ... o infection • Echocardiogram ... Goodpasture's cause ... hematuria, RBC casts ... progressive (crescentic) glomerulonephritis
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
Membranoproliferative Glomerulonephritis ... dysmorphic RBC, RBC casts ... microangiopathy (TMA ... #MPGN #nephrology ... #diagnosis #renal
Drug Induced Kidney Injury
 • Pre-Renal: NSAIDS, CNI, ACEI/ARB, IL-2 therapy, Diuretics CAR-T therapy
 • Osmotic
Injury • Pre-Renal ... therapy, Diuretics CAR-T ... #differential #diagnosis ... #algorithm #nephrology ... #Medications
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
- Differential Diagnosis ... Medications 2. ... TPN 5. ... #causes #potassium ... #high #nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
- Differential Diagnosis ... Medications 2. ... TPN 5. ... #causes #potassium ... #high #nephrology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Etiology: • Medications ... Antibiotics (Bactrim, PCN ... only if no clear cause ... STOP offending medications ... Treatment #potassium #nephrology
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
disequilibrium syndrome • Diagnosis ... Inhibitors of Na+K+2Cl ... Kidney stones caused ... Excretion #Diuresis #Nephrology ... #Pharmacology #Medications
Pragmatic diagnostic algorithm for hypokalemia. 
***Typical presentations: 
 • Vomiting: urine Na/Cl > 1.6, low urine
Pragmatic diagnostic ... K/creatinine (Cr ... Other medications ... continued in most cases ... differential #algorithm #nephrology
Post-Transplant Diarrhea - Diagnosis and Management Algorithm
Post-transplant diarrhea (≥ 3 loose or liquid stools per day)
Malabsorption workup in case ... ) ± Plasma CMV PCR ... switch to Aza if MPA ... Management #Algorithm #nephrology ... #renal #kidney