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Drug-induced renal disorders - The most commonly used nephrotoxic drugs

#Pharmacology #Nephrotoxicity #Drugs #Medications #Most #Common #DrugInduced
Drug-induced renal ... used nephrotoxic drugs ... #Pharmacology ... #Medications #Most ... KidneyInjury #AKI #Table
Hyperkalemia: Diagnostic algorithm
Decreased renal potassium excretion
 • Acute renal failure
 • Chronic renal failure
 • Drugs
Increased
algorithm Decreased ... renal potassium ... excretion • Acute renal ... failure • Chronic renal ... high: • Post-renal
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
- Differential Diagnosis ... Algorithm Extra-renal ... loss (Diarrhea) Renal ... #Algorithm #causes ... #potassium #low
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
• Refeeding syndrome ... Thyrotoxicosis Medications ... Renal Losses ... Non-renal losses ... #low #potassium
Acute Kidney Injury (AKI) - Differential Diagnosis Framework
Pre-Renal:
 • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Framework Pre-Renal ... Hypercalcemia, Renal ... Abdominal Compartment Syndrome ... , Medications Intra-Renal ... Autoimmune Post-Renal
Causes of Hypomagnesemia
Redistribution:
 - IV glucose
 - Correction of diabetic ketoacidosis
 - IV hyperalimentation
 - Refeeding
(steatorrhea) Renal ... osmotic diuresis - Potassium ... Tubulointerstitial renal ... #differential #medications ... #drugs #pharmacology
Causes of Metabolic Alkalosis - Differential Diagnosis
Chloride depletion syndromes
 • Gastrointestinal losses
    -
- Differential Diagnosis ... villous adenomas • Renal ... - Chloruretic drugs ... • Severe potassium ... #Differential #Diagnosis
Drugs associated with hypokalemia and hypomagnesemia

Hypokalemia
- Shift from extracellular fluid to intracellular fluid compartment
  -
Extrarenal Laxatives - Renal ... pump inhibitor - Renal ... renal Fanconi syndrome ... hypomagnesemia #Medications ... #differential #diagnosis
Hypokalemia Differential Diagnosis Algorithm

Low intake 
• poor oral intake 

Renal loss 
• Medication 
• Hypomagnesemia 
•
Algorithm Low ... oral intake Renal ... loss • Medication ... Nonreabsorbable anions • Renal ... • Bartter's syndrome
Hypomagnesemia - Etiologies by Mechanism

Decreased GI Uptake 
 - Poor dietary intake (particularly common in alcoholics)
diarrhea / IBD Renal ... Loses - Medications ... - Transient renal ... - Familial renal ... Low #Magnesium #Table