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diagnosis hepatology lfts algorithm aki failure hepatitis hepatocellular management abnormal aclf acutekidneyinjury albumin cancer causes chemistry cholestatic chronic classification elevated
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... • NAFLD • Cirrhosis ... Hepatopathy • Acute ... injury) • Ischemic ... #transaminitis
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Injury ... skeletal muscle and kidney ... #Cholestatic #Transaminitis ... #diagnosis #differential ... #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
> 20x normal - Acute ... CMV), Alcoholic cirrhosis ... #Injury #hepatology ... #LFTs #transaminitis ... #differential #
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... skeletal muscle, kidney ... Hepatocellular injury ... LFTs #Elevation #Transaminitis ... #diagnosis #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
hepatitis: < 1 • Cirrhosis ... cardiac muscle, RBC, Kidney ... Cardiac muscle, Kidneys ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... those with CLD (± cirrhosis ... Circulation Failure Kidney ... Injury (DILI) ... #Failure #Cirrhosis
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injury → liver ... test abnormalities ... Injury Differential ... #Injury #Differential
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Liver Injury: ... extrahepatic source - Tests ... hepatitis: < 1 • Cirrhosis
Indications for Albumin for Management of Cirrhosis • Large volume paracentesis (>5 liter) - 8g per
Management of Cirrhosis ... ascites removed • Acute ... kidney injury ( ... Indications #Management #Cirrhosis ... #treatment #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Algorithm for Transaminitis ... Congenital, Others, Cirrhosis ... Algorithm #diagnosis #hepatology
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