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Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
ALL (Acute Lymphoblastic ... age • 75% of ALL ... B-cell lineage ALL ... Mature B-cell ALL ... involvement • T-cell ALL
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
R-value: Serum (ALT ... /ULN ALT) / (Alk ... phos/ULN ALP) ... Liver Failure (ALF ... • AST/ALT > ALP
Treatment Schema for Standard-Risk Acute Lymphoblastic Leukemia Induction: • Vincristine, Steroid (dexamethasone), L-Asparaginase, Intrathecal (IT) methotrexate Consolidation
Vincristine, Steroid, Thiopurine ... Cytarabine #ALL
IBD - Assessment of Lack of Response (sLOR) - Differential Diagnosis Non-inflammatory mechanisms: • IBS • Fibrostenotic
#Inflammatory #BowelDisease
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
kidney, brain ALT ... for the liver ALP ... Transaminase, ALP ... / ULN ALT) / (ALP ... / ULN ALP)
Vancomycin and Dalbavancin (lipoglycopeptide antibiotics) - Antibiotics Class Overview Mechanism: Glycopeptide - inhibits cell wall synthesis
inhibits cell wall ... beta lactams – D-Ala-D-Ala ... Used for: all sorts
Heme Synthesis Pathway Enzymes 1. ALA Synthase 2. ALA Dehydratase 3. Porphobilinogen deaminase 4. UP Ill Synthase 5. UP Ill Decarboxylase 6. Coproporphyrinogen
ALA Synthase 2. ... ALA Dehydratase ... UP Ill Synthase ... UP Ill Decarboxylase
A 37-year-old woman initially presented with pancytopenia and found to have leukopenia (2.1 × 103/μL) with
and started on all-trans ... In addition to APL ... myeloid leukemia (AML ... ) t(8;21), AML with ... Rods #AuerRods #APL
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 Thiopurines in IBD Indications: • Steroid-sparing agents indicated for maintenance of remission in UC and CD •
Thiopurines in IBD ... Metabolism: • Thiopurine ... activity: avoid thiopurines ... 1.5mg/kg TDM (thiopurine ... #Inflammatory #BowelDisease
Persistent UC Symptoms Despite 5-ASA Therapies • Assess for Drug Adherence • Disease Activity Assessment (bloody
options: - Thiopurines
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