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diagnosis algorithm management causes differential ibd leukemia oncology treatment acute all hematology hemepath pathology pediatrics peds 5asa acutelymphoblasticleukaemia bcell boweldisease
Treatment Schema for Standard-Risk Acute Lymphoblastic Leukemia Induction: • Vincristine, Steroid (dexamethasone), L-Asparaginase, Intrathecal (IT) methotrexate Consolidation
Standard-Risk Acute Lymphoblastic ... Vincristine, Steroid, Thiopurine ... #ALL #Acute #Lymphoblastic
Presentation of malignant disease in children Pre-school (<5 years old) - Acute lymphoblastic leukaemia
old) - Acute lymphoblastic ... School-aged - Acute lymphoblastic ... Adolescence - Acute lymphoblastic
B-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma Clinical - Primarily a disease of childhood, 75% <6 yo - Increased
B-Cell Acute Lymphoblastic ... Leukemia/Lymphoblastic ... ALL #LBL #Acute #Lymphoblastic
Indolent T-Lymphoblastic Proliferation (iT-LBP) Features of iT-LBP: - May be seen in association with other malignancies (e.g.
Indolent T-Lymphoblastic ... similarities to T-lymphoblastic ... iTLBP #Indolent #TLymphoblastic
Persistent UC Symptoms Despite 5-ASA Therapies • Assess for Drug Adherence • Disease Activity Assessment (bloody
options: - Thiopurines
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
• Acute Lymphoblastic
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
• Acute Lymphoblastic
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
disturbance, Female, Thiopurine
Thiopurine De-escalation and IBD - Management Algorithm IBD Patient on Thiopurine Interested in Discontinuing Thiopurine Assess Disease Activity:
Thiopurine De-escalation ... IBD Patient on Thiopurine ... Discontinuing Thiopurine ... Indication for Thiopurine ... Waseem_AhmedMD #Thiopurine
Thiopurines in IBD Indications: • Steroid-sparing agents indicated for maintenance of remission in UC and CD •
Thiopurines in IBD ... Metabolism: • Thiopurine ... activity: avoid thiopurines ... 1.5mg/kg TDM (thiopurine ... @JeanDonet #Thiopurines
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