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ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
• Elevation in thrombin ... → thrormbin-induced ... the presence of thrombin ... can accelerate thrombin ... Scoring #diagnosis #hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
FVa to generate thrombin ... Thrombin, then primes ... large amounts of thrombin ... Cascade #platelet #thrombin ... diagnosis #models #hematology
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
Heparin, or Direct Thrombin ... prolonged #diagnosis #hematology
Thromboelastogram Interpretation Reaction Time (R Value): - Time till initiation of fibrin clot - Treatment: FFP, protamine K
assay representing thrombin-platelet ... #coagulation #hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Cirrhosis • Thrombus ... Algorithm #Causes #Hematology
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
inhibitors, direct thrombin ... comparison #diagnosis #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Arterial Embolism • Thrombus ... - Aortic mural thrombus ... Cardiac: - Atrial thrombus ... Left ventricular thrombus ... pathophysiology #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
drugs (e.g. direct thrombin ... #differential #hematology
Normal Thromboelastogram - Specific parameters represent the 3 phases of the cell-based model of haemostasis: initiation,
formation; i.e. thrombin ... ) #Diagnosis #Hematology
Effect of Direct Oral Anticoagulants on Hemostatic Tests Horizontal bars correspond to the approximate range of detectability
clotting time; TT = thrombin ... anticoagulation #hematology
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