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diagnosis differential rheumatology management causes erythematosus sle workup leukemia signs symptoms systemic algorithm aplastic cbc chronic cll hemeonc lymphocytic monoclonal
Aplastic Anemia Summary • Definition • Pathophysiology • DDx: AA vs Hypocellular MDS • Expectation •
Aplastic Anemia ... Definition • Pathophysiology ... #Aplastic #Anemia ... #diagnosis #oncology ... #hematololgy
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Artifact (redo CBC ... Non malignant hematologic ... following EtOH induced thrombocytopenia ... states • Non-hematologic ... Iron deficiency anemia
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
Criteria - Systemic Lupus ... NEUROLOGIC - HEMOLYTIC ANEMIA ... (<1000/MM3) - THROMBOCYTOPENIA ... absence of hemolytic anemia ... #Diagnosis #Rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... ) Blood (75%): Anemia ... Leucopenia/lymphopenia, Thrombocytopenia ... #Lupus #SLE #systemic ... symptoms #diagnosis #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Neurological 12% - Thrombocytopenia ... - Hemolytic anemia ... Diagnosis and Lupus ... #differential #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Causes of Thrombocytopenia ... decreased PLT count: CBC ... changes), high MCV anemia ... or if a primary hematologic ... Causes #Workup #hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
• Systemic Lupus ... Lymphocytic Leukemia (CBC ... Algorithm #Causes #Hematology ... #Oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
5) Symptoms of anemia ... or thrombocytopenia ... or thrombocytopenia ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... microangiopathy: Thrombotic thrombocytopenic ... usually IgG) (e.g. lupus ... differential #diagnosis #hematology ... #anemia
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Immune Aplastic Anemia ... infections/fevers • Thrombocytopenia ... #oncology #hematology
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