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management differential erythematosus lupus systemic table ana antibodies antinuclear treatment causes cerebritis classification cns cryoglobulinemia cryoglobulins diseases hemophagocytic hlh icl
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... their Disease Associations ... , autoimmune hepatitis ... diseases #diagnosis ... #table #rheumatology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in ... Rheumatology • ... Lupus (SLE): ANA ... #Rheumatology # ... diagnosis #associations
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Anti-dsDNA 60-80% Association ... overlap syndromes ... #Antinuclear #autoantibodies ... erythematosus #diagnosis ... #rheumatology #
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
occasions COMMON ASSOCIATIONS ... Autoimmune (Sjogren ... , SLE, Kikuchi dz ... chemotherapy) • Genetic syndromes ... #hematology #Differential
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Demyelinating Syndrome ... Disease, PRES Pathophysiology ... the formation of autoantibodies ... CNS #neurology #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Anti-Ro/SSA autoantibodies ... Differential Diagnosis ... rheumatologic diseases ... disorders (e.g. thyroid ... #Rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
), Sjogren's Syndrome ... Arthritis, Sjögren Syndrome ... Thyroid, Autoimmune ... ANA #patterns #rheumatology ... #diagnosis #differential
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... /aggregate) of CD4 ... and peripheral Thyroid ... phenomenon (16%) MSK ... #Rheumatology #
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
diseases: - 10% SLE ... Labs/Diagnosis: ... • Low serum C4 ... erythematosus (SLE ... classification #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... solid cancers • Autoimmune ... diseases: SLE++ ... treatment #summary #rheumatology
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