14 results
Spectrum of activity for systemic antifungal agents
Antifungals: 5FC, flucytosine; AMB, amphotericin B; ANI, anidulafungin; CAS, caspofungin;
activity for systemic antifungal ... agents Antifungals ... .2015.10.012 #Antifungal ... #antibiogram #management ... #pharmacology #
Rare Invasive Yeasts - Species and Antifungal Therapy

Cryptococcus, 
Geotrichum, 
Kodamaea, 
(Pichia)ohmeri, 
Malassezia, 
Pseudozyma, 
Rhodotorula, 
Saccharomyces, 
Saprochaete
- Species and Antifungal ... Trichosporon, Candida ... Invasive #Yeasts #Antifungal ... #Therapy #Management
Flutycosine - Antibiotics Class Overview
 - 
Mechanism: 5-FC interferes with DNA and protein synthesis.  Only
B for initial management ... - Virtually never ... for non-severe candida ... #Pharmacology #Antibiotics ... #Flutycosine #Antifungal
Antifungal Agents Frequently Used in Leukemia
Antibiogram:
 • Fluconazole
 • Itraconazole
 • Voriconazole
 • Posaconazole
 • Caspofungin
Antifungal Agents ... @ZhuoerXie #Antifungal ... #antibiogram #pharmacology ... #management #oncology
Antifungal Polyenes - Amphoterecin B, Abelcet, Ambisome - Antibiotics Class Overview

Mechanism: binds ergosterol in membrane and
Antifungal Polyenes ... 2nd-line for candida ... #Pharmacology #Antibiotics ... Overview #Polyenes #Antifungal
Antifungal Echinocandins  - Antibiotics Class Overview

Mechanism: Inhibit glucan synthesis in fungal cell wall by blocking
Antifungal Echinocandins ... Cidal vs Candida ... salvage therapy, never ... Anidulafungin #Pharmacology ... Echinocandins #Antifungal
Invasive Candidiasis (IC)

Diagnosis:
Culture:
 • Gold standard, but Slow (~2-3 days), 50% sensitivity
 • Blood Sample
 •
Tests Conduct antifungal ... Additional management ... Candidiasis #IC #antifungal ... #diagnosis #management ... #candida #auris
Antifungal Organ System Tissue Penetration

Concentrations in tissues and body fluids for each systemic antifungal agent relative
Antifungal Organ ... each systemic antifungal ... Red, from below level ... #Antifungal #OrganSystem ... Concentrations #Pharmacology
Candida Glabrata
Species of Candida Most Commonly Isolated in Bloodstream Infections
 • Symptomatic mucosal infection is detected
with persistent fever ... unresponsiveness to antifungal ... time to azole antifungals ... candidemia #diagnosis #management ... #fungemia #management
IDSA Recommendations for Treating Mucosal Candidiasis in HIV-AIDS
Oropharyngeal Candidiasis: Initial Episodes (Duration of Therapy: 7–14 days)
Preferred
Note: Systemic antifungals ... #Candidiasis #candida ... Prevention #Treatment #management ... infections #HIVAIDS #pharmacology