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diagnosis clinical differential rheumatology monkeypox vasculitis dermatology management photo anca mpv mpx lesions lupus algorithm classification comparison druginduced glomerulonephritis mpo
Monkeypox What? Monkeypox virus belongs to the family Poxviridae, subfamily Chordopoxvirinae, and genus orthopoxvirus Viral zoonotic disease that is
with someone with Mpox ... or ulcerative tonsillitis ... inguinal region • Mpox-related ... with confirmed mpox ... #Monkeypox #MPOX
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
associated with MPO ... polyangiitis - MPO ... polyangiitis - MPO ... Renal-limited - MPO ... #CANCA #PANCA #MPO
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
polyangiitis - MPO ... PR3 (80-90%) > MPO ... involvement - PR3>MPO ... Churg-Strauss) - MPO ... Anti-GBM disease - MPO
Examination revealed exudative tonsillitis (Panel A), strawberry tongue, and cervical adenopathy with tenderness. Skin examination revealed
revealed exudative tonsillitis ... ScarletFever #Rash #Tonsilitis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
myeloperoxidase (MPO-ANCA ... present in >90%, MPO ... Granulomas - MPO ... (10-40% ANCA +MPO ... 100 % Commonly MPO-ANCA
Lemierre’s Syndrome - Pathophysiology Lemierre’s is an infectious thrombophlebitis of the internal jugular vein. - It starts
as pharyngitis, tonsillitis
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
MPA > eGPA • MPO-ANCA
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
CD34, HLA-DR, MPO
ANCA Associated Vasculitis (AAV) - Auto-antibodies and Differential Diagnosis MPA → usually p-ANCA GPA → usually c-ANCA EGPA →
50% P-ANCA (MPO
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
anti-myeloperioxidase (MPO
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