94 results
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Function Tests (LFTs ... Hepatopathy • Acute ... Function #Tests #LFTs ... Diagnosis #hepatology #transaminitis
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
> 20x normal - Acute ... Injury #hepatology #LFTs ... #transaminitis
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... of cholestatic disease ... Alcoholic liver disease ... differential #Hepatology #transaminitis ... #LFTs #RValue #
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Hemochromatosis, Wilson's disease ... HELLP, Celiac disease ... hepatology #algorithm #Transaminitis ... #LFTs #hepatitis
Causes of False Elevation and Reduction in HbA1c

== False Elevation ==
Decreased RBC turnover 
• Iron, B-12,
• Asplenia Laboratory ... RBC turnover • Acute ... End-stage renal disease ... HbA1c #HgbA1c #Laboratory
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
Von Willebrand Disease ... GI. uterine) Laboratory ... factor VIII) Treatment ... VonWillebrand #Disease
Hepatobiliary Manifestations of Sickle Cell Disease
Acute sickle cell hepatic crisis:
 • Fever, acute onset RUQ pain,
of Sickle Cell Disease ... Acute sickle cell ... Supportive with treatment ... of SCD crisis Acute ... #SickleCell #Disease
ACE Trial: Randomized controlled trial of Ceftriaxone and doxycycline, with or without metronidazole, for the treatment
metronidazole, for the treatment ... of acute PID Wiesenfeld ... ID #Infectious Diseases ... #inflammatory #disease
IgG4-Related Disease
Clinical history:  Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
 •
IgG4-Related Disease ... with response to treatment ... relapse No specific laboratory ... hypergammaglobulinemia, ↑ acute ... IgG4 #Related #Disease
Hepatitis B (HBV) Serology

HBsAg - Presence denotes current HBV infection (chronic or acute)
HBV Core Antibody -
infection (chronic or acute ... Anti-HBcAg IgM - acute ... of active viral disease ... Serology #Diagnosis #Laboratory