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diagnosis differential hepatology injury causes pruritus abnormal dermatology dili elevation enzymes function gastroenterology generalized hepatitis hepatocellular interpretation management secondary systemic
Evaluation abnormal liver tests in pregnancy - Cholestatic Pattern - Hepatocellular Pattern #LFTs #transaminits #pregnancy #obgyn #obstetrics #hepatology #diagnosis
Evaluation abnormal liver ... in pregnancy - Cholestatic ... Hepatocellular Pattern #LFTs ... #transaminits # ... #differential #algorithm
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... Hepatocellular and Cholestatic ... R ≤ 2 = Cholestatic ... #Enzymes #LFTs ... #Transaminitis
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
(LFTs) Elevation ... ALT ≥ 3x ULN Cholestatic ... pattern ≤2: Cholestatic ... #FunctionTest #LFTs ... #Elevation #Transaminitis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Differential Diagnosis Algorithm ... for Transaminitis ... dz Cholestatic ... Burak @kwburak #LFTs
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... phosphatase) 2) Cholestatic ... Diagnosis #hepatology #algorithm ... #Transaminitis ... #LFTs #hepatitis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... RNA • R < 2: Cholestasis ... Obstruction: Cholestasis ... differential #Hepatology #transaminitis ... #LFTs #RValue #
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... Tests (LFTs) - ... (Drug-induced liver ... Function #Tests #LFTs ... Diagnosis #hepatology #transaminitis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Chronic - ongoing ↑ LFTs ... or symptoms of liver ... Mixed DILI • Cholestatic ... Drug #induced #Liver ... gastroenterology #algorithm
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Differential Diagnosis Algorithm ... • Others • Cholestatic ... • Others #LFTs ... Differential #Diagnosis #Algorithm
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... #Patterns #Liver ... Injury #hepatology #LFTs ... #transaminitis
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