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diagnosis hepatology differential algorithm hepatocellular injury abnormal bilirubin chemistry conjugated dili direct drug elevated elevation enzymes functiontest hepatitis hyperbilirubinemia idiosyncratic
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... ) - Causes of Hepatocellular ... and Cholestatic ... #Enzymes #LFTs ... #Transaminitis
Evaluation abnormal liver tests in pregnancy - Cholestatic Pattern - Hepatocellular Pattern #LFTs #transaminits #pregnancy #obgyn #obstetrics #hepatology #diagnosis
Evaluation abnormal liver ... in pregnancy - Cholestatic ... Hepatocellular Pattern #LFTs ... #transaminits #
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
(LFTs) Elevation ... ALT ≥ 3x ULN Cholestatic ... pattern ≤2: Cholestatic ... #FunctionTest #LFTs ... #Elevation #Transaminitis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Algorithm for Transaminitis ... def, Wilson's, Cholestatic ... dz Cholestatic ... Burak @kwburak #LFTs
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... RNA • R < 2: Cholestasis ... Obstruction: Cholestasis ... differential #Hepatology #transaminitis ... #LFTs #RValue #
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... Injury → liver ... phosphatase) 2) Cholestatic ... hepatology #algorithm #Transaminitis ... #LFTs #hepatitis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Chronic - ongoing ↑ LFTs ... or symptoms of liver ... Mixed DILI • Cholestatic ... Diagnosis #Management #gastroenterology ... #algorithm #gastroenterology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • Others • Cholestatic ... • Others #LFTs ... Diagnosis #Algorithm #Causes
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm 1. Definition: T.bili elevation + >20% conjugated 2. Obtain RUQ
= intrahepatic cholestasis ... non-ICU vs ICU causes ... MRCP, ERCP, liver ... Diagnosis #Algorithm #gastroenterology
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