64 results
Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Clinically ... suspect underlying hematologic ... disorders • Diagnosis ... #HES #Hematology ... #eosinophils #diagnosis
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... Kasabach-Merritt syndrome ... Gardner-Diamond syndrome ... #Differential #Diagnosis ... #hematology #rheumatology
Diagnosis of Cryoglobulinemia Vasculitis

1) Presence of cryoglobulin 
Circulating immunoglobulins that precipitate with cold temperature and dissolve
Diagnosis of Cryoglobulinemia ... not related to clinical ... Hyperviscosity syndrome ... and Ill) • Vascular ... #Rheumatology #
Approach to the Hypercoagulable State
Arterial thromboembolism
→ Cardiac rhythm monitoring, Echocardiogram, Vascular imaging
→ Test for APS, particularly
rhythm monitoring, Echocardiogram ... , Vascular imaging ... Hypercoagulable #Workup #hematology ... #diagnosis #algorithm ... #hematology #VTE
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
anti-synthetase syndrome ... - Classic triad ... arthritis (19% w/full triad ... at diagnosis). ... #rheumatology
Behcet's Syndrome - Diagnosis
Diagnostic Criteria for Behget's Syndrome (International Study Group for Behget's Disease):
 • Recurrent,
- Diagnosis Diagnostic ... test Most Common Clinical ... medium-large joints) • Vascular ... and peripheral vascular ... #criteria #rheumatology
Susac Syndrome - Clinical Triad
 - Central nervous system dysfunction
 - Branch retinal artery occlusion
 -
Susac Syndrome - ... Clinical Triad ... SusacSyndrome #Triad ... #Diagnosis #Management ... #Rheumatology
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Still's Disease Clinical ... triad: Fever, Arthralgia ... Differential Diaqnoses ... abnormalities • Muscular ... management #treatment #rheumatology
Bleeding risk calculators - HAS-BLED (atrial fibrillation) and IMPROVE (VTE prophylaxis for inpatients)
Important notes:
 • No
calculators - HAS-BLED (atrial ... prophylaxis and atrial ... studies suggest net clinical ... Anticoagulation #Factors #Hematology ... #Diagnosis
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Vascular Sludging ... ) Meltzer's Triad ... : • Clinical triad ... Labs/Diagnosis: ... classification #rheumatology