13 results
diagnosis hematology differential syndrome erythematosus hemophagocytic hlh lymphohistiocytosis oncology sle systemic treatment activation aids associated autoantibodies barre cerebritis dementia differentiation
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, bleeding, infections ... involvement • 30%: CNS ... pain, bleeding, infections ... leukostasis syndrome: CNS ... #Leukemia #Hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Disease, PRES Pathophysiology ... Erythematosus #SLE #CNS ... #neurology #rheumatology ... cerebritis #diagnosis #management
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Anti-cardiolipin (aPL ... - Anti-B2GP1 (aPL ... Other auto-immune, Infectious ... autoantibodies #signs #symptoms ... #differential #rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Incidence: common in APL ... the study) • Triggers ... ATRA treatment Pathophysiology ... Diagnosis: >3 symptoms ... #diagnosis #management
HIV-Associated Neurocognitive Disorder (HAND) Definition: HIV-Associated Neurocognitive disorders categories: • Asymptomatic neurocognitive impairment • Mild neurocognitive impairment • HIV dementia Pathophysiology: HIV frequently
HIV dementia Pathophysiology ... and infects the CNS ... early stages of infection ... • Depressive symptoms ... dementia #AIDS #Neurology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
nervous system (CNS ... SLE], AOSD) • Infection ... tests ↑ AST ↑ ALT ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
• Rheumatologic ... especially the CNS ... MC: CNS CSF: • ... Aspergillosis Pathophysiology ... Fungal #Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
(depending on CNS ... varies depending on trigger ... associated with infection ... HLH #Treatment #management ... #hematology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... that results in CNS ... Bilateral signs and/or symptoms ... Myelitis #diagnosis #management ... #neurology #differential
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
complete paralysis of all ... than one after symptom ... the underlying pathophysiology ... Syndrome #diagnosis #management ... #neurology
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