19 results
Aplastic Anemia and Bone Marrow Failure Syndromes with Pancytopenia

Fanconi Anemia
Acquired Aplastic Anemia
Dyskeratosis Congenita & Telemore Biology
Aplastic Anemia ... and Bone Marrow ... Failure Syndromes ... #anemia #diagnosis ... #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
- Differential Diagnosis ... Algorithm Decreased ... Megakaryopoiesis • Aplastic ... Non-lmmune: • HELLP Syndrome ... #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
and Differential Diagnosis ... Algorithm Consumption ... HLH syndrome 5. ... FISH • Acquired Aplastic ... #Algorithm #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
and Differential Diagnosis ... Algorithm Consumption ... HLH syndrome 5 ... FISH • Acquired Aplastic ... #Algorithm #Hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
= Hypocellular bone ... Constitutional Syndromes ... • Suggested by bone ... Anemia #oncology #hematology ... #diagnosis #management
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... dys- (abnormal) -plastic ... • Bone marrow ... Myelodysplastic #Syndrome ... Management #treatment #hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
Algorithmic Approach ... - Differential Diagnosis ... Non-hemolytic: ACD, Aplastic ... aciduria, Drugs (e.g ... #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
Hypoproliferative (i.e. bone ... Hypogonadism • Bone ... marrow failure: Aplastic ... Production #Index #hematology ... #differential #diagnosis
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
- Differential Diagnosis ... Algorithm Decreased ... • Marrow Aplasia ... • Secondary (e.g ... #Hematology
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
• A clinical diagnosis ... antiinflammatory properties e.g ... #Rheumatology # ... diagnosis #management ... #Dermatology