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diagnosis hematology differential algorithm management oncology classification sle workup bruising druginduced elevatedmcv erythematosus extravascular hemolysis intravascular macrocytosis mcv mds myelodysplastic
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... (MAHA) - Abnormal ... #Normocytic #Anemia ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... • Pernicious Anemia ... #Macrocytic #Anemia ... Diagnosis #Algorithm #Causes ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... usually IgG) (e.g. lupus ... antibiotics are the most frequently ... Extravascular #Causes ... #anemia
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Poisoning • Anemia ... Chronic Disease Normal ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Causes of Anemia ... Deficiency (Eg Causes ... TlBC > 18% • Anemia ... #Microcytic #Anemia ... #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... RBC Production - Normal ... • Anemia of Chronic ... Diagnosis #Algorithm #Causes ... #Hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Framework for Anemia ... thalassemia • Anemia ... some patients) Normal ... differential #diagnosis #causes ... #hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... - CRP: Usually normal ... Positive in 60-80% of cases ... Management #Summary #rheumatology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Drug-induced AIHA - Abnormal ... immune-complex hemolytic anemia ... Diagnosis #Algorithm #Causes ... #Hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
cases, drug-dependent ... CRP - Usually normal ... Discontinuation of causal ... - CRP: Usually normal ... comparison #table #rheumatology
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