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diagnosis differential management antibodies cryoglobulinemia dermatology mpo pr3 algorithm ana antibody antineutrophil antinuclear aortitis associated associations autoantibodies autoimmune canca causes
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
ANCA-Associated ... Vasculitis A group ... PR3 Anti-GBM disease ... 100%, PR3+ 50%, frequently ... PR3 #Diagnosis #Rheumatology
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Classification of ... Vasculitis Vasculitis ... small vessels - ANCA-associated ... dermatomyositis #Size #Classification ... #Diagnosis #Rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
connective tissue disease ... Vasculitis: • ... Renal-limited vasculitis ... antibodies #diagnosis #rheumatology ... #diseases
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis: + MPO-ANCA ... (Granulomatous disease ... atherosclerotic disease ... differential #diagnosis #rheumatology ... #classification
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Associations ANA ... c-ANCA - Vasculitis ... granulomatosis p-ANCA ... - Vasculitis, e.g ... diagnosis #table #rheumatology
Vasculitis - Break down based on vessel size Distribution of vessel involvement by large vessel vasculitis,
Vasculitis - Break ... by large vessel vasculitis ... basement membrane; ANCA ... #Diagnosis #Rheumatology ... Medium #Large #Classification
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
involvement: Anti-GBM Disease ... (C-ANCA): GPA > ... (P-ANCA): eGPA, ... Glomerulonephritis #Vasculitis ... diagnosis #algorithm #rheumatology
Frequency of ANCA Positivity in Different Conditions ANCA-Associated Vasculitis • GPA - PR3-ANCA 75%, MPO-ANCA 20%, 5%
Frequency of ANCA ... Vasculitis • ... Renal-limited vasculitis ... • Drug-induced vasculitis ... PR3 #diagnosis #rheumatology
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Non-Infectious Aortitis: • Vasculitides ... Nodosa (PAN), ANCA ... associated vasculitis ... : IgG4-Related Disease ... Differential #Diagnosis #rheumatology
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Vasculitis Involving ... 50% Cutaneous Vasculitis ... • ANCA Associated ... : • Behcet Disease ... #dermatology #rheumatology
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