82 results
Osteoporosis: Pathogenesis and risk factors

 • Age > 30 (post-peak bone mass)
 • Post-menopausal women ->
30 (post-peak bone ... Decr estrogen • Bone ... - IBD • Chronic ... #Osteoporosis #pathophysiology ... #signs #symptoms
Anemia - Underproduction Diagnostic Algorithm
 - Iron deficiency anemia
 - Anemia of chronic inflammation
 - Anemia
- Anemia of chronic ... - Anemia of chronic ... kidney disease ... deficiency - Probable bone ... #differential #workup
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
Pancytopenia - Workup ... Alcoholism Bone ... Metastatic Disease ... #Pancytopenia #Workup ... Diagnosis #Algorithm #Hematology
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
and duration of symptoms ... resolve within one ... , Chronic spontaneous ... urticaria, Chronic ... Urticaria #diagnosis #rheumatology
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
Pancytopenia - Workup ... Alcoholism Bone ... Metastatic Disease ... #Pancytopenia #Workup ... Diagnosis #Algorithm #Hematology
Gaucher Disease 

Pathophsiology
 • Lysosomal storage disorder
 • Deficiency of ß-glucocerebrosidase
• Accumulation of glucosylceramide in macrophages
Diagnosis
Gaucher Disease ... Pathophsiology ... Osteonecrosis, bone ... #Gauchers #Disease ... Diagnosis #Signs #Symptoms
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... Inflammatory Conditions: Rheumatologic ... Vasculitides, IBD, Celiac disease ... • Infections: Chronic
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... Chronic leukemia ... onset of symptoms ... extramedullary disease ... #Leukemia #Hematology
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
• Ligament • Bone ... or nerve root Symptoms ... : • Acute or chronic ... Joint #Pain #MSK #rheumatology ... #approach #workup
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
• Anemia of chronic ... deficiencies: Chronic ... kidney disease, ... Hypogonadism • Bone ... Production #Index #hematology