47 results
Hyperparathyroidism - Primary vs Secondary vs Tertiary 
Lab Comparison:
 • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
signs, Fragile bones ... easily/weakness, Bone ... pain Psychiatric Symptoms ... Hyperparathyroidism #diagnosis #endocrinology ... Secondary #Tertiary #pathophysiology
Causes of Dizziness - Vertigo - Differential Diagnosis Algorithm
True Vertigo - Illusion of Rotary Movement
Peripheral Vestibular
- Vertigo - Differential ... vomiting, auditory symptoms ... Media • Temporal Bone ... Imbalance, neurologic symptoms ... Vertigo #Neurology #Differential
Hypercalcemia - Differential Diagnosis Algorithm
Elevated PTH (High or normal):
 • Primary Hyperparathyroidism
 • Familial Hypocalciuric Hypercalcemia
Low
Hypercalcemia - Differential ... Miscellaneous - Bone ... Hypercalcemia #Differential ... Diagnosis #Algorithm #causes ... #endocrinology
Causes of Hypercalcemia
Hypercalcemia due to increased bone Ca2+ resorption:
 • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
Causes of Hypercalcemia ... due to increased bone ... Hypercalcemia #Causes ... #differential # ... calcium #high #endocrinology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
ALP) Elevation - Differential ... Intestine - Other causes ... Most common symptoms ... symptoms - Pain ... ALP #Elevation #Differential
Causes of Hypercalcemia
Parathyroid gland structure-related
 • Primary hyperparathyroidism
 • Parathyroid adenoma
 • Parathyroid hyperplasia
 • Parathyroid
Causes of Hypercalcemia ... D) Increased bone ... Hypercalcemia #Causes ... #endocrinology ... #diagnosis #differential
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... • softening of bones ... collection with EDTA Pathophysiology ... mineralization Symptoms ... Phosphatase: • Other causes
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Incr IGF1 • Bone ... lipolysis Signs/Symptoms ... #FeedbackLoop #endocrinology ... #pathophysiology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Platelet Disorders - Differential ... practices that could cause ... pylori test (GI symptoms ... candidate) - Bone ... Platelet #Disorders #Differential
Bone Lesion on X-Ray - Differential Diagnosis Algorithm 
Exostotic
 • Osteochondroma
Asymptomatic &/or Non-Active Bone Scam
 •
Bone Lesion on X-Ray ... - Differential ... Constitutional Symptoms ... BoneLesion #XRay #MSK #Differential ... #Orthopedics #Causes