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diagnosis management differential oncology algorithm workup causes rheumatology hepatology dermatology hemolytic pancytopenia signs symptoms syndrome aplastic autoimmune clinical leukemia mgus
Aplastic Anemia and Bone Marrow Failure Syndromes with Pancytopenia Fanconi Anemia Acquired Aplastic Anemia Dyskeratosis Congenita & Telemore Biology
Aplastic Anemia ... and Bone Marrow ... Pancytopenia Fanconi Anemia ... Acquired Aplastic Anemia ... #diagnosis #Hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... with hypocellular bone ... Treatment: • Consider ... diagnosis #management #treatment ... #hematology
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
hyperplasia of bone ... breakdown • Anaemia ... Hemolysis #Hemolytic #Anemia ... Causes #Workup #Hematology
Anemia - Underproduction Diagnostic Algorithm - Iron deficiency anemia - Anemia of chronic inflammation - Anemia
Anemia - Underproduction ... Iron deficiency anemia ... - Anemia of chronic ... deficiency - Probable bone ... Underproduction #Algorithm #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Non malignant hematologic ... effect following treatment ... states • Non-hematologic ... Iron deficiency anemia ... Algorithm #Causes #Hematology
Treatments for Sickle Cell disease #Sicklecell #sicklecelldisease #sicklecellanemia, #sicklecells #sickle #hematology #anemia #clinical #pediatrics #FOAM #FOAMed
Treatments for Sickle ... sicklecells #sickle #hematology ... #anemia #clinical
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Autoimmune Hemolytic Anemia ... Autoimmune Hemolytic Anemia ... Spherocytes • Treatment ... transient hemolysis • Treatment ... #hematology #diagnosis
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Hypoproliferative (i.e. bone ... Index < 2: • Anemia ... Hypogonadism • Bone ... Hyperproliferative (i.e. bone ... Production #Index #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
cytopenias (usually anemia ... • Bone marrow ... only curative treatment ... Diagnosis #Management #treatment ... #hematology #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
= Hypocellular bone ... • Suggested by bone ... hypoplasia/fatty bone ... Treatment: ... #oncology #hematology
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