34 results
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
Paget’s Disease: ... excessive bone ... formation MSK ... PagetsDisease #pathophysiology ... #diagnosis #signs
Causes of Hypercalcemia
Hypercalcemia due to increased bone Ca2+ resorption:
 • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
Causes of Hypercalcemia ... due to increased bone ... calcium)-alkali syndrome ... #differential #diagnosis ... calcium #high #endocrinology
Causes of Hypercalcemia
Parathyroid gland structure-related
 • Primary hyperparathyroidism
 • Parathyroid adenoma
 • Parathyroid hyperplasia
 • Parathyroid
D) Increased bone ... of bone Malignancy ... Multiple myeloma (bone ... • Milk-alkali syndrome ... #endocrinology
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
inflammatory disorder of bone ... • Bone and joint ... Rule out other causes ... - MRI: inflammation ... osteoarticular and skin disease
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Weakness, Incr CK • Bone ... Myopathy (Also caused ... Erythematosus #SLE #MSK ... #signs #symptoms ... #diagnosis
Pott's Disease in Tuberculosis - Diagnosis and Management Summary
Epidemiology:
 - Typically from TB endemic areas
 -
Pott's Disease in ... extrapulmonary cases ... decreased reflexes Pathophysiology ... of bacilli to bone ... : - MRI is modality
Osgood-Schlatter Disease - MSK Radiology
Imaging Findings:
 • Infrapatellar fat-pad edema with loss of the patellar tendon
- MSK Radiology ... fragmentation and mild bone ... • MRI is more sensitive ... marrow edema and bony ... #msk
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
g/dl LLN B - Bony ... more: • Clonal bone ... focal lesions on MRI ... plasmacytoma, POEMs syndrome ... Gammopathies #MGUS #diagnosis
Fat Embolism Syndrome
Trauma to the long bone or pelvis accounts for —9096 of cases. The diagnosis
Fat Embolism Syndrome ... Trauma to the long bone ... accounts for —9096 of cases ... Pathophysiology ... #Diagnosis #Signs
Vascular Joint Pain - Differential Diagnosis Algorithm 
 - Constant Pain (Ischemia)
 - Acute Onset
 -
Peripheral Vascular Disease ... fractured long bone ... Marfan's Syndrome ... • Dislocated Bone ... #Orthopedics #Causes