56 results
signs management clinical complications pocus syndrome differential hepatology msk algorithm disease hematology orthopedics alkaline alp carcinoma gammopathy liver mgus monoclonal
Hyperparathyroidism - Primary vs Secondary vs Tertiary Lab Comparison: • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
signs, Fragile bones ... easily/weakness, Bone ... pain Psychiatric Symptoms ... Hyperparathyroidism #diagnosis ... Secondary #Tertiary #pathophysiology
Hypercalcemia of Malignancy - Pathophysiology PTH-mediated • Parathyroid cancer • Ectopic production: Small cell lung cancer, ovarian
of Malignancy - Pathophysiology ... D - Increased renal ... resorption in the bone ... Cell of lung, Renal ... #Differential #Diagnosis
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
Most cases diagnosed ... collection with EDTA Pathophysiology ... mineralization Symptoms ... neuropathy • Renal ... : - Renal failure
Osteoporosis: Pathogenesis and risk factors • Age > 30 (post-peak bone mass) • Post-menopausal women ->
30 (post-peak bone ... Decr estrogen • Bone ... #Osteoporosis #pathophysiology ... #signs #symptoms ... #diagnosis
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
- Differential Diagnosis ... Most common symptoms ... Pregnancy - Renal ... symptoms - Pain ... #Differential #Diagnosis
Gaucher Disease Pathophsiology • Lysosomal storage disorder • Deficiency of ß-glucocerebrosidase • Accumulation of glucosylceramide in macrophages Diagnosis
Gaucher Disease Pathophsiology ... in macrophages Diagnosis ... Osteonecrosis, bone ... Gauchers #Disease #Diagnosis ... #Signs #Symptoms
Colchicine Toxicity Naturally-occurring plant alkaloid [Autumn Crocus and Glory Lilly] 2-24 hrs • Severe GI distress
2-7 days • Bone ... Rhabdomyolysis • Renal ... Toxicity #Toxicology #Symptoms ... #Signs #Diagnosis
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Weakness, Incr CK • Bone ... Complications #pathophysiology ... #signs #symptoms ... #diagnosis
Malignant Bone Tumors: Pathogenesis of X-ray appearance • Metastatic bone tumors (aka. cancerous cells from systemic
Malignant Bone Tumors ... • Metastatic bone ... . thvroid. and renal ... Signs/Symptoms: ... Malignant #Radiology #Diagnosis
Renal Cell Carcinoma (RCC) - Diagnosis and Management Summary Clinical features - Classic triad (flank pain, hematuria,
(RCC) - Diagnosis ... Symptoms of metastatic ... Bone scan is indicated ... patients with bone ... Carcinoma #RCC #Diagnosis
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