12 results
diagnosis signs complications syndrome anorexianervosa ascorbicacid bulimianervosa disease endocrinology erythematosus genetics glucocorticoids hyperparathyroidism ileal lupus management msk musculoskeletal nutrition pediatrics
Gaucher Disease Pathophsiology • Lysosomal storage disorder • Deficiency of ß-glucocerebrosidase • Accumulation of glucosylceramide in macrophages Diagnosis
Gaucher Disease ... Pathophsiology ... Osteonecrosis, bone ... infarcts, osteoporosis ... Diagnosis #Signs #Symptoms
Hyperparathyroidism - Primary vs Secondary vs Tertiary Lab Comparison: • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
signs, Fragile bones ... /osteoporosis, Kidney ... easily/weakness, Bone ... /joint pain Psychiatric ... Secondary #Tertiary #pathophysiology
Osteoporosis: Pathogenesis and risk factors • Age > 30 (post-peak bone mass) • Post-menopausal women ->
Osteoporosis: Pathogenesis ... 30 (post-peak bone ... Decr estrogen • Bone ... #pathophysiology ... #signs #symptoms
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
Glucocorticoid-Induced Osteoporosis ... -> Reduced Bone ... Formation, Increased Bone ... #pathophysiology ... #signs #symptoms
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Weakness, Incr CK • Bone ... Normal CK • Osteoporosis ... Complications #pathophysiology ... #signs #symptoms
Prader-Willi Syndrome: Pathogenesis and clinical findings • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Syndrome Signs/Symptoms ... Infertility • Decr Bone ... mineral density and osteoporosis ... Syndrome #genetics #pathophysiology
Paget’s Disease: Pathogenesis and Clinical Findings • Incr serum CTx - marker of bone resorption •
CTx - marker of bone ... resorption • Lytic bone ... formation #PagetsDisease ... #pathophysiology ... diagnosis #signs #symptoms
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
cause excessive bone ... turnover -> Incr bone ... hearing loss #PagetsDisease ... #pathophysiology ... diagnosis #signs #symptoms
Short Bowel Syndrome - Acute and Chronic Adverse Signs and Symptoms of Ileal Resection • Dehydration
Adverse Signs and Symptoms ... Nephropathy • Bone ... Disease, Osteoporosis ... Syndrome #Signs #Symptoms ... Ileal #Resection #pathophysiology
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
Mucous membranes • Bone ... • Persons with psychiatric ... musculoskeletal symptoms ... Psychiatric symptoms ... #AscorbicAcid #Pathophysiology
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