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diagnosis hematology management oncology hemolytic algorithm cardiology classification infectiousdiseases workup chronic extravascular fungal hemolysis intravascular leukemia pulmonary testing treatment vasculitis
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... • AIHA: warm, cold ... drug induced • Infections ... #Differential #
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Warm AIHA • Cold ... circulation - Infections ... immune-complex hemolytic anemia ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... (e.g. primary cold ... #differential # ... diagnosis #hematology ... #anemia
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Clinical Presentation ... • Symptoms of anemia ... younger pts) Differential ... Symptoms: High fevers ... #hematology #diagnosis
Tachypnea - Differential Diagnosis Framework Definitions • Tachypnea: Respiratory rate > 20/min, shallow breathing in adults •
Tachypnea - Differential ... Tachypnea: • Anemia ... dysfunction; toxic ingestions ... • Temperature/FEVER ... Tachypnea #Hyperpnea #Differential
Generalized Weakness - Differential Diagnosis Framework "l feel weak": • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis •
Generalized Weakness - Differential ... : CHF, valves, COPD ... ILD, OSA, pHTN, Anemia ... Rhabdomyolysis, Critical ... #Diagnosis #causes
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... : • Fever • Fatigue ... /fevers • Thrombocytopenia ... and petechiae Causes ... and thymoma DDX
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
and clinical associations ... Infections 2. ... symptoms - Headache, fever ... Urticaria #diagnosis #rheumatology ... #comparison #table
Causes of Pericardial Effusion - Differential Diagnosis Infectious: • Viral: Enterovirus, Herpesvirus, Adenovirus, Parvovirus • Bacterial: Mycobacterium
Causes of Pericardial ... Effusion - Differential ... Diagnosis Infectious ... : • Rheumatologic ... Mediterranean Fever
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Agglutination - Cold ... inclusions - If infection ... bartonella (oroya fever
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