13 results
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... effusions, weight gain ... initiation • Differential ... #management #hematology ... #oncology
Oncologic Emergencies - Differential Diagnosis Framework

HEMATOLOGIC ONCOLOGIC EMERGENCIES:
Hyperviscosity Syndrome:
 • Spontaneous bleeding
 • Shortness of breath
- Differential ... Diagnosis Framework HEMATOLOGIC ... of breath • Neurologic ... EMERGENCIES: Tumor ... #differential #
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
change disease • Hematologic ... Interleukin-2) • Tumor ... #AKI #Cancer #Oncology ... #Differential # ... Classification #Nephrology
Causes of Seizures - Differential Diagnosis Algorithm
Unprovoked - Epilepsy:
 • Focal: Simple, Complex
 • Generalized: Absence,
of Seizures - Differential ... vasoconstriction syndrome ... • Structural: Tumor ... Neurocysticercosis, PML ... Algorithm #Causes #neurology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
, APML, CLL Acute ... develop leukostasis syndrome ... lysis syndrome: ... #Leukemia #Hematology ... #Oncology #Diagnosis
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Diagnosis Neurologic-Centered ... capillary leak syndrome ... • Schnitzler syndrome ... #Diagnosis #hematology ... #oncology
Summary of Oncologic Emergencies

Neutropenic fever:
- Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... antibiotics TLS (tumor-lysis ... syndrome): - Hematologic ... (~20 %) and APL ... fever, weight gain
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
capillary leak syndrome ... et diutinum Neurologic ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Tumor-associated ... - SLE Neurologic ... Lymphadenopathy • Tumor-associated ... #joint #pain #differential ... #diagnosis #rheumatology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
transformation to AML ... blood count with differential ... progression to AML ... #diagnosis #hematology ... #oncology