94 results
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... -> Allantoin (High ... #TumorLysis #Syndrome ... #TLS #Pathophysiology
Ear Pain (Otalgia) - Differential Diagnosis Framework

Primary Otalgia 
 - Pain that originates from the ear
associated with infection ... - Ramsay Hunt syndrome ... Temporomandibular joint syndrome ... Nerve V: • TMJ syndrome ... • Infection
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
SAME, Cushing Syndrome ... • HTN, High Aldosterone ... Renin secreting tumor ... , Gitelman syndrom ... Diagnosis #Algorithm #causes
Causes of Back Pain - Differential Diagnosis Algorithm
Always assess for red flags. If no red flags,
Causes of Back Pain ... nocturnal pain, high ... • Fracture • Tumor ... /lnfection • Unresolved ... • Cauda Equina Syndrome
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... immature blasts and high ... WBC count cause ... • Pathophysiology ... Spontaneous if high
Causes of HyperKalemia - Differential Diagnosis
Increased extracellular K+:
 • Tissue injury
 • Hemolysis
 • Rhabdomyolysis
 •
Causes of HyperKalemia ... Rhabdomyolysis • Tumor ... lysis syndrome ... glycosides • High ... transfusion • Error of injection
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Diuretics (late) • High ... , Gitelman Syndrome ... hyperaldosteronism • High ... Renin-secreting tumor ... Algorithm #Nephrology #Causes
Causes of Primary Amenorrhea - Differential Diagnosis Algorithm
No onset of menarche by age 16 with secondary
Causes of Primary ... Ovarian Etiology - High ... ) • 45, XO Turner ... Irradiation • Tumor ... Diagnosis #Algorithm #Causes
Infectious Causes of Adrenal Insufficiency
Anatomical distribution of vessels to the adrenal makes the gland prone to
Infectious Causes ... primary adrenal infection ... Waterhouse-Friderichsen syndrome ... #Causes #Adrenal ... endocrinology #infectiousdiseases
Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
 • High Al, Low R - Primary aldosteronism
 • High Al, High
Hypertensive: • High ... aldosteronism • High ... Al, High R - Secondary ... Renin-secreting tumor ... Algorithm #nephrology #causes