42 results
Tumor lysis syndrome (TLS) - Pathophysiology:
→ Massive tumor cell lysis
→ Release of large amounts of K+,
Tumor lysis syndrome ... (TLS) - Pathophysiology ... : → Massive tumor ... TumorLysis #syndrome #TLS ... #Pathophysiology
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... (TLS) Tumor Cell ... TumorLysis #Syndrome #TLS ... #Pathophysiology
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
feel weak": • Infectious ... : UMN (stroke, tumor ... Polyneuropathy, ALS ... ↓, Malignancy, Infection ... Diagnosis #causes #neurology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis vs Tumor ... /- rasburicase Tumor ... : Lysis of tumor ... rate or large tumor ... #Leukostasis #Tumor
Causes of Peripheral Weakness with Sensory Changes - Differential Diagnosis Algorithm
Radiculopathy:
 • Disc
 • Spondylosis
 •
Spondylosis • Tumor ... • Infection ... • Trauma • Tumor ... • Diabetes • Tumor ... Weakness #Sensory #Neurology
Causes of Facial Weakness - Differential Diagnosis Algorithm
Forehead Sparing = Central cause
  - Most commonly
- Intracranial tumor ... Palsy (70-75%), Infection ... , Compression Tumor ... Algorithm #Causes #neurology
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of
Tumor lysis syndrome ... acutekidneyinjury #Pathophysiology ... #Presentation #TLS
Tumor Lysis Syndrome (TLS) Pathophysiology
Culprits: ALL, Burkitt, SCLC
Cells all die at once = ↑Phos, ↓Ca, ↑K,
Tumor Lysis Syndrome ... (TLS) Pathophysiology ... worsens above #Tumor ... Lysis #Syndrome #TLS ... #Pathophysiology
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework
Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis
90%:
 -
Pulmonary Renal ... Myositis MIMICS: - Infections ... : Hantavirus infection ... failure, cardiac tumor ... Kumfer @AnnKumfer #Pulmonary
Altered Mental Status - Differential Diagnosis
 • Neurologic: Stroke, Cerebral hypoxia, Cerebral hemorrhage, Seizure, Trauma, TBI,
Differential Diagnosis • Neurologic ... , Trauma, TBI, Tumor ... Thyroid disease • Infectious ... Recreational drugs, Toxic ingestions