28 results
Tumor lysis syndrome (TLS) - Pathophysiology:
→ Massive tumor cell lysis
→ Release of large amounts of K+,
Tumor lysis syndrome ... (TLS) - Pathophysiology ... : → Massive tumor ... #TumorLysis #syndrome ... #TLS #Pathophysiology
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... (TLS) Tumor Cell ... #TumorLysis #Syndrome ... #TLS #Pathophysiology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis vs Tumor ... /- rasburicase Tumor ... : Lysis of tumor ... rate or large tumor ... #Leukostasis #Tumor
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework
Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis
90%:
 -
Pulmonary Renal ... Myositis MIMICS: - Infections ... : Hantavirus infection ... failure, cardiac tumor ... Kumfer @AnnKumfer #Pulmonary
Tumor Lysis Syndrome (TLS) Pathophysiology
Culprits: ALL, Burkitt, SCLC
Cells all die at once = ↑Phos, ↓Ca, ↑K,
Tumor Lysis Syndrome ... (TLS) Pathophysiology ... worsens above #Tumor ... #Lysis #Syndrome ... #TLS #Pathophysiology
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
feel weak": • Infectious ... : UMN (stroke, tumor ... Polyneuropathy, ALS ... ↓, Malignancy, Infection ... Diagnosis #causes #neurology
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of
Tumor lysis syndrome ... acutekidneyinjury #Pathophysiology ... #Presentation #TLS
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Myelitis, Trauma, Tumor ... Motor Nerves: ALS ... Guillain-Barre syndrome ... Lambert Eaton Syndrome ... differential #diagnosis #neurology
Alice in Wonderland Syndrome
What? Metamorphophsia - Distortions of the visual perceptions with changes in size (micro
in Wonderland Syndrome ... common cause) • Infection ... (e.g. stroke, tumor ... Alice #Wonderland #Syndrome ... #diagnosis #neurology
Causes of Seizures - Differential Diagnosis Algorithm
Unprovoked - Epilepsy:
 • Focal: Simple, Complex
 • Generalized: Absence,
vasoconstriction syndrome ... • Structural: Tumor ... brain injury • Infectious ... Algorithm #Causes #neurology