9 results
Tumor lysis syndrome (TLS) - Pathophysiology:
→ Massive tumor cell lysis
→ Release of large amounts of K+,
Tumor lysis syndrome ... (TLS) - Pathophysiology ... phosphate crystals #TumorLysis ... #syndrome #TLS ... #Pathophysiology
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... Hyperkalemia #TumorLysis ... #Syndrome #TLS ... #Pathophysiology
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS
Laboratory TLS:
 • Uric
Classification of Tumor ... Lysis Syndrome ... gluconate #TumorLysis ... #diagnosis #management ... #oncology
Tumor Lysis Syndrome - Workup and Management

Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Tumor Lysis Syndrome ... - Workup and Management ... #Lysis #Syndrome ... #diagnosis #management ... #oncology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Lysis Syndrome ... Leukostasis: • Pathophysiology ... hyperviscosity syndrome ... • Pathophysiology ... TLS #diagnosis #management
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... wandering_er #Tumor ... #Lysis #Syndrome ... #TLS #oncology ... #management #UricAcid
Tumor Lysis Syndrome (TLS) Pathophysiology
Culprits: ALL, Burkitt, SCLC
Cells all die at once = ↑Phos, ↓Ca, ↑K,
Tumor Lysis Syndrome ... (TLS) Pathophysiology ... #Lysis #Syndrome ... #TLS #Pathophysiology ... #oncology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... Differentiation #Syndrome ... APML #diagnosis #management ... #hematology #oncology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
Diagnosis and Management ... malignancy Pathophysiology ... pancreatic islet cell tumor ... Beckwith Wiedemann syndrome ... Endocrinology #Treatment #Pathophysiology