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diagnosis differential nephrology causes potassium algorithm hypokalemia management low hypophosphatemia lysis oncology pathophysiology treatment tumor uricacid acutekidneyinjury cairoandbishop diuresis diuretics
Pathophysiology of Tumor Lysis Syndrome (TLS) Tumor Cell Lysis -> Release of DNA • Purines -> Hypoxanthine /
Lysis Syndrome ... (TLS) Tumor Cell ... -> Allantoin (High ... Hypocalcemia • Hyperkalemia ... #TLS #Pathophysiology
Workup of Hypercalcemia - Differential Diagnosis Algorithm High or Normal PTH: • Hyperparathyroidism: Parathyroid adenoma, Parathyroid hyperplasia,
Workup of Hypercalcemia ... disease, Milk Alkali Syndrome ... disease, Viral Syndromes ... Diagnosis #Algorithm #Workup ... #nephrology #PTH
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of
Tumor lysis syndrome ... hyperuricemia, #hyperkalemia ... #Presentation #TLS ... #Workup #tumorlysissyndome
Hypokalemia - Differential Diagnosis Algorithm Extra-renal Losses: • Normal Acid-Base: Low intake • Metabolic acidosis: Gl tract
Hypokalemia - Differential ... • HTN, High Aldosterone ... Renin secreting tumor ... @priti899 #Hypokalemia ... potassium #low #nephrology
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... cytotoxic therapies in high-burden ... treatments) occur in high ... #Lysis #Syndrome ... #TLS #oncology
Reflex Testing - Causes of Hyporeflexia and Hyperreflexia Focal Hyporeflexia: • Radiculopathy, Mononeuropathy, Polyneuropathy, Acute stroke,
Hyporeflexia: • Hypercalcemia ... Guillain-Barré syndrome ... Hyperthyroidism, Serotonin syndrome ... differential #diagnosis #table ... #neurology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
immature blasts and high ... leukapheresis - TLS ... Spontaneous if high ... hydration - Hyperkalemia ... #TLS #diagnosis
Hypokalemia Differential Diagnosis Algorithm Hypertensive: • High Al, Low R - Primary aldosteronism • High Al, High
Hypokalemia Differential ... Hypertensive: • High ... Renin-secreting tumor ... #Hypokalemia # ... Diagnosis #Algorithm #nephrology
Causes of HyperKalemia - Differential Diagnosis Increased extracellular K+: • Tissue injury • Hemolysis • Rhabdomyolysis •
Causes of HyperKalemia ... Rhabdomyolysis • Tumor ... lysis syndrome ... glycosides • High ... blockers - MCW Nephrology
Workup for Hypophosphatemia - Differential Diagnosis Framework Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia Measure Urine Fractional Excretion
Workup for Hypophosphatemia ... , Tumor genesis ... • Normal or High ... Low PTH: - High ... #phosphate #nephrology
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