5804 results
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
respiratory failure Diagnosis ... Medical time to diagnosis ... Other possible diagnosis ... in differential diagnosis ... Sclerosis #neurology #diagnosis
Incomplete spinal cord syndromes (ISCS)
 • Central - Small Lesion - Suspended sensory deficit, classic cape
Disproportionate motor (UMN ... Ipsilateral weakness (UMN ... paraparesis (mixed UMN ... and LMN types) ... spinalcord #syndromes #diagnosis
Upper Motor Neuron (UMN) lesions are lesions occurring anywhere in the CNS from the brain up
Motor Neuron (UMN ... the differential diagnosis ... However, in UMN ... UMC & LMN lesions ... UMN lesions are
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
- Differential Diagnosis ... Infection • Neuro: UMN ... stroke, tumor), LMN ... #Differential #Diagnosis
Floppy Baby Syndrome
 • Infantile Botulism
 • Acute Flaccid Myelitis
 • Guillain Barre
 • Neonatal Myasthenia
is crucial • UMN ... LMN signs - Assess ... #differential #diagnosis
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
- Differential Diagnosis ... Gravis - Lack of UMN ... /LMN signs - Lack ... #Differential #Diagnosis
Bilateral LMN palsy with tongue weakness, wasting and fasciculations.  →  Bulbar motor Neuron disease

Note
Bilateral LMN palsy ... differentiates this from an UMN ... fasciculations #LMN
Spinal Cord Disorders - Differential Diagnosis Framework

Spinal cord neurological lesion:
Clinical findings:
 • Symptoms and signs below
- Differential Diagnosis ... : Areflexia UMN ... plantar response LMN ... spinalcord #disorders #diagnosis
Multiple Sclerosis - Summary

Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
Examination: • UMN ... Multiple Sclerosis Diagnosis ... lesions) McDonald diagnostic ... Multiple #sclerosis #diagnosis
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Phosphatase, ALT ≥ 3x ULN ... Transaminase, ALP ≥ 2x ULN ... Value = (ALT / ULN ... ALT) / (ALP / ULN ... Transaminitis #diagnosis