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diagnosis lupus oncology hemeonc hemophagocytic hlh lymphohistiocytosis syndrome chronic druginduced erythematosus leukemia lymphocytic systemic antinxp2 antinxp2dm classification comparison dermatomyositis dil
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Summary myelo ... old, ~10,000 new cases ... Allogeneic stem cell ... only curative treatment ... #treatment #hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Diagnosis and Management ... Summary • Epidemiology ... Positive in 60-80% of cases ... life-threatening • Treatment ... #Summary #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Erythematosus - Summary ... severe disease Treatment ... #Summary #diagnosis ... #rheumatology # ... management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytic Leukemia - Summary ... incompetent • CLL ... non-Hodgkin lymphoma SLL ... microglobulin Treatment ... workup #oncology #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... ) - Summary Overview ... uw_IMresidency #CLL ... Leukemia #oncology #hematology ... hemeonc #diagnosis #management
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Epidemiology: -10% of all ... Discontinuation of causal ... Usual therapeutic management ... comparison #table #rheumatology ... #diagnosis #management
Major Clinical Trials and Evidence Summary for Transfusion Thresholds in Critical Care TRICC - NEJM 1999 -
Trials and Evidence Summary ... NEJM 1999 - ICU FOCUS ... unnecessary and cause ... in critically ill ... Transfusion #Thresholds #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Autoimmune diseases: SLE ... Drugs, Unknown cause ... Lymphohistiocytosis #diagnosis #management ... #treatment #summary ... #rheumatology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... normal in mild cases ... Chronic Management ... Avoid meds that ... #treatment #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
Lymphohistiocytosis (HLH) Treatment ... steroids • In mild cases ... autoimmune disease, treatment ... Options for severe cases ... #management #hematology
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