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Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
Syndrome Step ... /nephritic syndromes ... hematuria (RBC casts ... #Syndrome #Comparison ... #Algorithm #Nephrology
Differentiation Between Nephrotic Syndrome and Nephritic Syndrome 
== Nephrotic Syndrome ==
Onset - Insidious 
Edema - ++++
Blood
Syndrome and Nephritic ... Syndrome == Nephrotic ... Red blood cell casts ... Red blood cell casts ... #Syndrome #Nephritic
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm
Acute Kidney Injury (AKI) - Acute increase
Causes of Acute ... Acute Kidney Injury ... • Hepatorenal syndromes ... Epithelial cell casts ... Interstitial Nephritis
Urinary Casts and Disease Associations
Hyaline - May be nonspecific; seen in normal individuals or during severe
Urinary Casts and ... breakdown of cellular casts ... heme-granular casts ... are seen in acute ... 34t5DgJ #Urinary #Casts
Urine Microscopy - Casts
Acellular Casts
 • Hyaline Casts - Consists of only precipitated Tamm-Horsfell protein without
suggestive of acute ... and chronic kidney ... suggestive of nephrotic ... sydnrome • Pigment ... Urine #Microscopy #nephrology
Algorithmic Approach to Acute Interstitial Nephritis
When to suspect AIN? (not sensitive)
 • AKI, AKD, rapidly progressive
Algorithmic Approach ... Nephritis When ... sterile pyuria, WBC casts ... proteinuria, granular casts ... #nephrology #diagnosis
Simplified Approach to Acute Kidney Injury (AKI)
1) IS THIS AN EMERGENCY? 
Is there a dialysis indication
Kidney Injury ( ... : Hypovolemia, Low ... Urinary obstruction, Nephrotoxic ... PROBLEM ~80% of AKI cases ... for WBCs, RBCs, casts
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... - AKI Workup Algorithm ... electrolytes, urea ... • Interstitial nephritis ... Differential #Diagnosis #nephrology
Acute Kidney Injury - Classification
Prerenal:
 • Dehydration
 • Heart failure (a.k.a. cardiorenal syndrome)
 • Liver failure
Acute Kidney Injury ... tubular necrosis (causes ... interstitial nephritis ... #Kidney #Injury ... Classification #diagnosis #nephrology
Common causes of Acute Kidney Injury AKI - Differential Diagnosis
HEMODYNAMIC
 • Cardiac failure: Impaired forward flow,
Common causes of ... Acute Kidney Injury ... inhibitors, hepatorenal syndrome ... Interstitial Nephritis ... Differential #Diagnosis #nephrology