11 results
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
Renal Tubular Defects ... loop of Henle Gitelman ... Localization #Nephron #Defects ... #Pathophysiology ... #Nephrology
Hypomagnesemia - Etiologies by Mechanism

Decreased GI Uptake 
 - Poor dietary intake (particularly common in alcoholics)
- Gitelman ... Genetic defects ... Differential #Diagnosis #Low ... #Magnesium #Table ... Classification #Causes
Causes of Hypomagnesemia - Differential Diagnosis Algorithm
GI LOSS - FeMg < 2-2.5% or 24h Urine Mg
Causes of Hypomagnesemia ... nephrocalcinosis (FHHNC) • Gitelman's ... syndrome • Thiazide ... ab • Genetics defects ... Hypomagnesemia #Magnesium #Low
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
Inherited Defects ... ascending limb Gitelman ... Epithelial #Inherited #Defects ... #Kidney #Nephrology ... #Differential #Table
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
with coagulation defects ... Elevated Liver tests, Low ... child * Severe cases ... Severe coagulation defects ... hematology #diagnosis #table
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Pregnancy Three syndromes ... with coagulation defects ... Elevated Liver tests, Low ... Severe coagulation defects ... Diagnosis #Comparison #Table
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Causes of Metabolic ... tubule diuretic effect ... tubule reabsorptive defect ... furosemide-like lesion) • Gitelman ... #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
alkalosis • Normal/low ... , Gitelman syndrome ... mineralocorticoid-like effect ... the indicated causes ... urine #Algorithm #nephrology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Affects 1:25,000 ... - gastric and breast ... DDX - Other causes ... : • Nephrotic syndrome ... (Epstein-Barr syndrome
HIV-Associated Neurocognitive Disorder (HAND)

Definition:
HIV-Associated Neurocognitive disorders categories:
• Asymptomatic neurocognitive impairment
• Mild neurocognitive impairment
• HIV dementia

Pathophysiology:
HIV frequently
HIV dementia Pathophysiology ... barrier (BBB), and infects ... ARVs can have low ... volume • Patchy areas ... The clinical syndrome