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algorithm hematology management neurology classification cardiology pathophysiology pulmonary hemolytic nutrition rheumatology dermatology disorders secondary workup acidosis infectiousdiseases oncology systemic table
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
anemia, Thalassemia ... Sideroblastic anemia ... Schistocytes - Hemolytic uremic ... Morphology #Atlas #key #diagnosis ... #differential #
Altered Mental Status - Differential Diagnosis • Neurologic: Stroke, Cerebral hypoxia, Cerebral hemorrhage, Seizure, Trauma, TBI,
Diagnosis • Neurologic ... Electrolyte disturbance, Uremia ... Hypercarbia, Vitamin deficiency ... Thyroid disease • Infectious ... #Diagnosis #Causes
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Poisoning • Anemia ... Marrow Failure • Anemia ... Inflammation, Chronic Infection ... Myelodysplasia #Anemia
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... -12, or folate deficiency ... Hypertriglyceridemia • Uremia ... • Hemolytic anemia ... #DM2 #Differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... TTP), Hemolytic uremic ... G6PD deficiency) ... #differential # ... #anemia
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Diagnosis Platelet ... Reactive: • Anemia ... blood loss (Fe deficiency ... ) • Infection/ ... #Diagnosis #causes
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
particular degree of anemia ... Index < 2: • Anemia ... failure: Aplastic anemia ... #differential # ... diagnosis #calculation
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
anemia, Chronic ... disease anemia ... Echinocyte): Artifact, Uremia ... RBC #Morphology #differential ... #diagnosis #hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach to Anemia ... Sideroblastic anemia ... ACD, Aplastic anemia ... Macroangiopathic, Infections ... MatthewHoMD #Anemia
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
Differential diagnosis ... toxin-mediated hemolytic-uremic ... • Severe B12 deficiency ... macroangiopathic hemolytic anemia ... #diagnosis #hematology
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