34 results
diagnosis hematology management differential algorithm thrombocytopenia disorders pathophysiology transfusion anticoagulation bruising causes comparison risk thresholds afib bleed blood checklist gastroenterology
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
Inherited Qualitative Platelet ... • Defect of adhesion ... Single isolated platelets ... without platelet ... failure Grey Platelet
Idiopathic Thrombocytopenic Purpura Clinical: • Gingival • Menorrhagia • GI bleeding • Intracranial
Menorrhagia • GI bleeding ... children) • Platelets ... only for severe bleeding ... extremely low platelet
Indications for Transfusion Packed RBCs • Hgb <7 g/dL or hematocrit <21% in a patient with uncompromised
hemoglobinopathy Platelets ... • < 30,000 and bleeding ... postoperative bleeding ... < 100,000 and bleeding ... Platelet transfusions
Bleeding and Bruising - Differential Diagnosis Algorithm • Vascular System Defect - Congenital vs Acquired •
Bleeding and Bruising ... vs Acquired • Platelet ... vs Acquired #Bleeding
Thresholds for Transfusion of Platelets in Adults Major surgery or invasive procedure, no active bleeding - ≤
Transfusion of Platelets ... procedure, no active bleeding ... neurosurgery, no active bleeding ... Surgery with active bleeding ... #Management #Platelets
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 Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
common inherited bleeding ... bruising • Skin bleeding ... • Prolonged bleeding ... Laboratory • Normal platelet
Mechanisms Driving Increased Thrombosis and Bleeding in Liver Disease Increased Thrombosis Increased Platelet-Vesset Wall Interaction •
Thrombosis and Bleeding ... Thrombosis Increased Platelet-Vesset ... #Thrombosis #Bleeding
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Sequestration Disordered Platelet ... Coagulation #Bleeding
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Thrombocytopenia and Platelet ... History: - Prior platelet ... - History of bleeding ... epistaxis, gingival bleeding ... Thrombocytopenia #Platelet
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Findings: • Bleeding ... Findings: • Bleeding ... Findings in DIC: • Platelet ... Thrombocytopenia - Platelet ... transfusion for bleeding
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