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Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
/nephritic syndromes ... the patient have glomerular ... hematuria (RBC casts ... dysmorphic RBCs in urine ... #Algorithm #Nephrology
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome:
 - Acute poststreptococcal 
glomerulonephritis 
 - Rapidly progressive
Nephrotic Syndromes ... Nephritic syndrome ... : - Acute poststreptococcal ... Classification #Nephrology ... Recommended Text: Nephrology
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
Nephrotic Syndromes ... Nephritic syndrome—due ... RBC casts in urine ... #Nephrotic #Syndromes ... #Proteinuria #Nephrology
Causes of Hyponatremia - Differential Diagnosis Algorithm
Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
Causes of Hyponatremia ... Pain/Post-op • Neurologic ... Cirrhosis • Nephrotic ... Hypo-osmolar urine ... #Nephrology #Differential
Causes of Hyponatremia - Differential Diagnosis Algorithm
Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
Causes of Hyponatremia ... Pain/Post-op • Neurologic ... Cirrhosis • Nephrotic ... Hypo-osmolar urine ... #Nephrology #Differential
Volume Based Approach to Hyponatremia
Hypovolemic, Serum uric acid >4
 • Urine Na <20: Extra-renal losses
 •
Based Approach to Hyponatremia ... failure, Cirrhosis, Nephrotic ... syndromeUrine ... SatyaPatelMD #Volume #Hyponatremia ... #sodium #low #nephrology
Hematuria Workup and Diagnosis Algorithm
 • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
repeat testing • Acute ... • Evidence of glomerular ... → Refer to Nephrology ... cystoscopy • Refer to Nephrology ... if cause not identified
Causes of Hyponatremia - Differential Diagnosis Algorithm
Hypovolemia, UNa > 20: 
 • Renal losses, Diuretic excess,
Causes of Hyponatremia ... UNa > 20: • Acute ... , UNa < 20 • Nephrotic ... Diagnosis #Algorithm #Causes ... #nephrology
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
of Glomerular Bleeding ... disease - Alport syndrome ... pain hematuria syndrome ... • Nutcracker syndrome ... #urology #nephrology
Atlas of Urine Microscopy Findings
 • Epithelial cells - Normal
 • Renal tubular cells - Acute
Atlas of Urine Microscopy ... tubular cells - Acute ... brown cast” - Necrotic ... protein indicating acute ... key #diagnosis #nephrology