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Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Guillain-Barre Syndrome ... than females Guillain-Barre ... bulbar muscles Guillain-Barre ... • Areflexia Guillain-Barre ... #Barre #Syndrome
Reflex Testing - Causes of Hyporeflexia and Hyperreflexia
Focal Hyporeflexia: 
 • Radiculopathy, Mononeuropathy, Polyneuropathy, Acute stroke,
Reflex Testing - Causes ... polyneuropathy (e.g ... Guillain-Barré syndrome ... Hyperthyroidism, Serotonin syndrome ... diagnosis #table #neurology
Guillain–Barré syndrome (GBS)
(aka: Landry–Guillain–Barré–Strohl syndrome:
	Most common cause of acute flaccid paralysis
	Rapidly progressive ascending paralysis & areflexia
	Autonomic
GuillainBarré syndrome ... (GBS) (aka: Landry–GuillainBarré–Strohl ... syndrome:  Most ... common cause of ... cord lesion on MRI
Etiologies of Peripheral Neuropathy
 • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism
 • Medication-induced: ART, Antibiotics,
• Inflammatory/AI ... : CIDP, Guillain-Barre ... Paraprotein-associated (POEMS syndrome ... differential #diagnosis #causes ... #neurology
Causes of Hyponatremia - Differential Diagnosis Algorithm
Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
Causes of Hyponatremia ... • Reduced GFR, AKI ... Hypo-osmolar urine ... Uosm < 100 mmol/kg ... #Hyponatremia #Nephrology
Causes of Hyponatremia - Differential Diagnosis Algorithm
Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
Causes of Hyponatremia ... • Reduced GFR, AKI ... Hypo-osmolar urine ... Uosm < 100 mmol/kg ... #Hyponatremia #Nephrology
Guillain-Barré Syndrome (GBS)
Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness
Epidemiology:
 • Incidence: 1
Guillain-Barré Syndrome ... Incidence: 1 to 2 cases ... demyelinating or axonal • MRI ... - Spinal MRI may ... #Barre #Syndrome
Cauda Equina Syndrome Overview

Cauda Equina Syndrome:
 • Prevalence: 1:33,000-100,000 ppl/yr
 • Incidence: 1.5-3.4 million ppl/yr
 •
- Emergency Causes ... Tethered cord • Guillain-Barre ... Imaging studies: • MRI ... differential #diagnosis #causes ... #neurology