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Lupus Nephritis Classification Algorithm

#Lupus #Nephritis #Classification #Algorithm #diagnosis #differential #types #rheumatology #nephrology #renal
Lupus Nephritis ... #Classification ... #Algorithm #diagnosis ... differential #types #rheumatology ... #nephrology #renal
Renal Involvement in Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#Renal #diseases #SLE #Systemic #Lupus #Erythematosus #venn #nephrology
Renal Involvement ... #diseases #SLE ... Erythematosus #venn #nephrology ... #nephritis #classification ... #types #rheumatology
Hematuria Workup and Diagnosis Algorithm
 • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
Hematuria Workup and Diagnosis ... nephrolithiasis • Symptoms ... → Refer to Nephrology ... for renal biopsy ... Workup #urology #blood
Management of Lupus Nephritis
Lupus nephritis (LN) in 10 to 40% of SLE
Hallmark = proteinuria 20.5 g/g
Management of Lupus ... or 0.5 g/day → renal ... by 12 months Classification ... #rheumatology # ... nephrology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Abdominal pain (20%) Renal ... disease (30%): ... Glomerulonephritis Myositis(5%) Blood ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
• 1ml blood/liter ... of glomerular disease ... causes #urology #nephrology ... #renal #urine # ... blood
Hematuria in Post-Renal Transplant Patient
Prevalence up to 12% in the postrenal transplant patient
 • Bacterial: Escherichia
, Busulfan • Disease ... #differential #diagnosis ... #kidney #blood ... #urine #management ... #treatment #nephrology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Cerebrovascular Disease ... thrombosis and/or blood-brain ... #rheumatology # ... cerebritis #diagnosis ... #management #treatment
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... & renal involvement ... #SLE #Summary #diagnosis ... #rheumatology # ... management
Urinary Casts and Disease Associations
Hyaline - May be nonspecific; seen in normal individuals or during severe
Urinary Casts and Disease ... and concentrated urine ... tubulointerstitial nephritis, renal ... Differential #Microscopy #Diagnosis ... #Nephrology