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differential glomerular nephrotic proteinuria diseases hematuria nephritic syndrome workup acute aki blood classification glomerulonephritis hyperkalemia injury intercellularshift kidney membranoproliferative microscopy
Hematuria Workup and Diagnosis Algorithm • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
Hematuria Workup and Diagnosis ... Algorithm • Confirm ... • Evidence of glomerular ... → Refer to Nephrology ... by UW IM Residency
Nephritic vs Nephrotic Syndrome Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes. Step
hematuria (RBC casts ... dysmorphic RBCs in urine ... Nephrotic #Syndrome #Comparison ... #Algorithm #Nephrology ... #Diagnosis
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
- Differential Diagnosis ... Algorithm Persistent ... • Drugs Glomerular ... #Proteinuria #Nephrology ... #Algorithm #Causes
Glomerular Diseases - Nephritic and Nephrotic Syndromes Nephritic syndrome—due to GBM disruption. Hypertension. t BUN and creatinine.
Glomerular Diseases ... syndrome—due to GBM ... RBC casts in urine ... #Proteinuria #Nephrology ... #Diagnosis
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
- Differential Diagnosis ... Algorithm Red ... blood cells on urine ... #Differential #Diagnosis ... #Algorithm #Causes
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
Algorithm - Approach ... Cytomegalovirus; GBM ... arbitrarily defined as urine ... #diagnosis #glomerular ... nephrotic #syndrome #nephrology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Injury - AKI Workup Algorithm ... and Differential Diagnosis ... osmolarity If cause ... ANCA, ANA, Anti-GBM ... #nephrology #causes
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
GN • Active Urine ... dysmorphic RBC, RBC casts ... immune deposits on EM ... Glomerulonephritis #MPGN #nephrology ... #diagnosis #renal
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
Immunofluorescence Microscopy (IM ... RPGN • Anti-GBM ... #diseases #nephrology ... #pathology #comparison ... #table #diagnosis
Causes of Hyperkalemia - Reduced Excretion - Differential Diagnosis Algorithm Reduced flow through distal nephron - TTKG
Causes of Hyperkalemia ... Algorithm Reduced ... nephron - TTKG > 7, Urine ... IntercellularShift #Nephrology ... #Algorithm #Causes
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